Biological Modelling Using CellML and MATLAB

نویسندگان

  • Adam Reeve
  • Alan Garny
  • Andrew K. Miller
  • Randall D. Britten
چکیده

CellML is an XML-based file format for describing mathematical models, with the aim of simplifying the creation, exchange and reuse of models. There are a number of software tools for modelling biological processes that can read and write CellML files. In this paper, we describe the ability of the OpenCell modelling environment to export CellML files to a number of different programming languages. We give an example of how OpenCell can be used together with MATLAB, a popular language for mathematical modelling, in cardiac cellular electrophysiology. Limitations and areas for future improvement in code export from OpenCell are also addressed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Modelling biological modularity with CellML.

In recent years advances in the construction of mathematical models of biological systems have yielded an array of valuable constructs. The authors seek to provide a 'leading practice' method for implementing modularised kinetic mass-action models in order to obtain a number of advantages in model construction, validation and derived insights. The authors advocate the consideration of 'accounti...

متن کامل

Integrating software packages for the analysis of biological pathway networks

Interactions at the cellular level are essential for maintaining the fundamental life processes in biological systems. The relationships that are established due to the biochemical reactions occurring within the cells often give rise to extremely complex network structures that may be conveniently represented by bipartite graphs; such networks are often known as biological pathway graphs (BPGs)...

متن کامل

Biophysical annotation and representation of CellML models

MOTIVATION CellML is an implementation-independent model description language for specifying and exchanging biological processes. The focus of CellML is the representation of mathematical formulations of biological processes. The language captures the mathematical and model building constructs well, but does not lend itself to capturing the biology these models represent. RESULTS This article...

متن کامل

Biophysical annotation and representation of CellML models

Motivation: CellML is an implementation-independent model description language for specifying and exchanging biological processes. The focus of CellML is the representation of mathematical formulations of biological processes. The language captures the mathematical and model building constructs well but does not lend itself to capturing the biology these models represent. Results: This paper de...

متن کامل

CellML and associated tools and techniques.

We have, in the last few years, witnessed the development and availability of an ever increasing number of computer models that describe complex biological structures and processes. The multi-scale and multi-physics nature of these models makes their development particularly challenging, not only from a biological or biophysical viewpoint but also from a mathematical and computational perspecti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010